Senior Scientist PK-PD Modelling-00000OCP
Description
The Senior Scientist conducts advanced PK/PD modeling research utilizing available modeling techniques, with a focus on Oncology, Immunology and/or Infectious Diseases compounds. Primarily supports early development clinical and translational activities by defining the dose-concentration-pharmacological effects relationships of drugs using modeling and simulation methodologies, from data acquired at various development stages. Performs population PK and PK/PD analyses to support decision making in the development of compounds. Uses state-of-the-art computer simulation techniques to predict various possible trial outcomes aimed at optimizing trial designs. Has technical responsibility for organizing, executing, and reporting modeling and simulation research. Collaborates with colleagues and groups within or outside Molecular Based Drug Development (MBDD) as needed and, under minimal supervision, is responsible for executing technical analyses pertaining to his/her field. Can act as the responsible MBDD Leader at Clinical Team level.
Qualifications
• PhD or MS with 4-8 years of relevant industry experience in Pharmaceutical Sciences, (Clinical) Pharmacology, Physiology or Chemical/Biomedical Engineering.
• The successful candidate has a minimum of 2-5 years of pharmaceutical development experience or at least 3-5 years of post-doctoral experience in the various aspects of modeling and simulation.
• This preferably includes hands-on experience with the population approach in describing PK/PD systems using clinical pharmacology data.
• A working knowledge of preclinical or clinical pharmacokinetics, drug metabolism, PK/PD modeling principles and statistics is required.
• Experience with NONMEM, R and/or other modeling and simulation software is a clear advantage.
• Has a keen interest in planning, conducting, evaluating and reporting PK/PD studies. Good communication and interpersonal skills are essential.
• A good knowledge of the English language is a prerequisite.
• Experience in early development projects in the Oncology, Immunology and/or Infectious Diseases area would be advantageous.
What’s in it for you…?
“Caring for the world, one person at a time…”
As an employee we consider you as our most valuable asset. We take your career seriously.
As part of a global team in an innovative environment your development is key and our day-to-day responsibility.
Through e-university, on the job training, various projects and programs, we ensure your personal growth.
Our benefits make sure we care for you and your family now and in the future.
Primary Location:Europe/Middle East/Africa-Belgium-Antwerp-Beerse
Organization: Janssen Pharmaceutica N.V. (7555)
Job Function: Pharmacokinetics
Description
The Senior Scientist conducts advanced PK/PD modeling research utilizing available modeling techniques, with a focus on Oncology, Immunology and/or Infectious Diseases compounds. Primarily supports early development clinical and translational activities by defining the dose-concentration-pharmacological effects relationships of drugs using modeling and simulation methodologies, from data acquired at various development stages. Performs population PK and PK/PD analyses to support decision making in the development of compounds. Uses state-of-the-art computer simulation techniques to predict various possible trial outcomes aimed at optimizing trial designs. Has technical responsibility for organizing, executing, and reporting modeling and simulation research. Collaborates with colleagues and groups within or outside Molecular Based Drug Development (MBDD) as needed and, under minimal supervision, is responsible for executing technical analyses pertaining to his/her field. Can act as the responsible MBDD Leader at Clinical Team level.
Qualifications
• PhD or MS with 4-8 years of relevant industry experience in Pharmaceutical Sciences, (Clinical) Pharmacology, Physiology or Chemical/Biomedical Engineering.
• The successful candidate has a minimum of 2-5 years of pharmaceutical development experience or at least 3-5 years of post-doctoral experience in the various aspects of modeling and simulation.
• This preferably includes hands-on experience with the population approach in describing PK/PD systems using clinical pharmacology data.
• A working knowledge of preclinical or clinical pharmacokinetics, drug metabolism, PK/PD modeling principles and statistics is required.
• Experience with NONMEM, R and/or other modeling and simulation software is a clear advantage.
• Has a keen interest in planning, conducting, evaluating and reporting PK/PD studies. Good communication and interpersonal skills are essential.
• A good knowledge of the English language is a prerequisite.
• Experience in early development projects in the Oncology, Immunology and/or Infectious Diseases area would be advantageous.
What’s in it for you…?
“Caring for the world, one person at a time…”
As an employee we consider you as our most valuable asset. We take your career seriously.
As part of a global team in an innovative environment your development is key and our day-to-day responsibility.
Through e-university, on the job training, various projects and programs, we ensure your personal growth.
Our benefits make sure we care for you and your family now and in the future.
Primary Location:Europe/Middle East/Africa-Belgium-Antwerp-Beerse
Organization: Janssen Pharmaceutica N.V. (7555)
Job Function: Pharmacokinetics