Johnson & Johnson companies are equal opportunity employers.
Principal Scientist, Radiosynthesis-9489140122
Description
Janssen Research & Development, L.L.C., a Johnson & Johnson Company, is hiring a Principal Scientist, Radiosynthesis to be located in Spring House, PA.
Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion, Janssen Research & Development, LLC is proud to be an equal opportunity employer.
Position is available in the Janssen Discovery Sciences, Isotope Synthesis Group located in Spring House Pa. The successful candidate will be responsible for the design, planning and synthesis of intermediates, stable and radioactive isotopic-labeled drug candidates and for the preparation of drug metabolites. Contingent on performance and experience the role may eventually include supervisory responsibilities for staff and postdocs.
Responsibilities include but are not limited to: Works closely with a small team of scientists involved in the production and analysis of carbon-14 and tritium labeled compounds; Assures projects move from inception to completion safely and in an acceptable timeframe and that specifications are attained which meet company goals; Ensures that appropriate standards are met in the analysis, release and stability investigation of isotopically labeled compounds; Communicates closely with internal and external partners and provides regular updates on project status; Liaises with study directors and project teams and provides up to date information on project status; Focuses on the synthesis and optimization of carbon-14 and tritium labeling methodologies as well as implementation of novel approaches to ensure timely delivery of highest quality products; Acts as a single point of contact for internal and external organizations requesting radiolabeled products; Responsible for planning own work and executing purification and release analysis of stable isotope labeled and carbon-14 and tritium labeled compounds. Assures agreed deadlines are met for delivery of analytically released compounds. Actively contributes to the planning of the operation and ensures appropriate use of resources internally and externally; Interacts with Bio-analytical and DMPK functions to ensure the provision of isotopically labeled (15N, 2H, 3H, 13C, 14C, etc.) compounds for various studies; Develops HPLC preparative purification methods for radiolytically decomposed radiolabeled materials; Analyzes and purifies radiolytically decomposed radiolabeled materials as required; Works closely with radiosynthesis scientists for optimization of carbon-14 and tritium labeling methodologies as well as implementation of novel synthesis approaches; Communicates project status and interacts on a regular basis with project leaders and functional (DMPK, Bio-analysis, and research) scientists; Ability to work in a team and constructively influence decision making; Writes reports and delivers presentations, which are clear, organized, focused, and intellectually sound; If training is required, the candidate must have a demonstrated aptitude for learning new techniques and operating varied pieces of scientific instruments and equipment; Maintains and follows all company SOPs and safety rules; Handles radioactivity in a safe manner and keeps equipment and laboratory environment free of radioactive contamination. Assures personnel, ecological and radiation safety standards are met; Appropriately documents and archives analytical raw data, datasheets and reports for analysis of isotopically and non-isotopically labeled compounds; supplies receipts and safety monitoring according to corporate policies; Tracks laboratory compound inventories and orders and replenishes own common lab supplies. Interacts with external suppliers, sales, and service individuals; Remains current in state-of-the-art techniques and technologies and ensures their implementation where appropriate; Takes responsibility for publishing activities and research in scientific and professional journals; May supervise staff in future where applicable; Assures state-of-the-art methodology, technology and equipment in the laboratory. Assures that all assisting study personnel have adequate training and understanding of all applicable SOPs; Complies with internal and external health and safety regulations and guidelines; Writes and follows Standard Operating Procedures; Completes all annual training requirements; Performs other duties as assigned.
Qualifications
PhD radiochemist with a minimum of 10 years of radiosynthesis experience working in a pharmaceutical radioisotope laboratory preparing and analyzing compounds labeled with carbon-14 and tritium is required
Extensive knowledge and expertise of with all aspects of radioisotope handling, methodologies and techniques is required
Extensive knowledge of the US NRC rules and regulations for radiation safety is required
Ability to manage multiple scientific projects; make sound scientific interpretations and judgments is required
Previous managerial experience is required
Proven track record of delivering high quality projects on time
Extensive technical experience in the performance of a range of niche radiolabeled reaction types and transformations that minimize the risk of contamination to personnel and environment is required
Extensive understanding of the pharmaceutical drug development business is required
Proven ability to lead and direct professional staff
Track record of innovation confirmed by senior-authored scientific publications in the radioisotope field
Thorough knowledge of analytical instruments, methodologies and techniques used for LC-MS and preparative HPLC chromatography and chiral methods development is required
Knowledge of NMR spectroscopy is required
Demonstrated ability to partner successfully in a fast paced, goal-oriented environment by building consensus and by impacting outcomes with limited supervision
Excellent verbal, partnering and communication skills with an innate ability to develop and articulate sound ideas and arguments to project leaders, scientific partners or clients
Proven track record of developing small molecule synthesis strategies and hands-on experience in synthetic chemistry completing synthesis projects is required
Can work independently with continuous attention to detail and safety
Possesses a strong analytical mindset coupled with strategic thinking abilities
Able to present clearly and effectively to scientists and all levels of management within and outside Discovery Science both locally and globally
Able to read, understand and verify accuracy of protocols and reports
Up to 5% travel, international and domestic may be required
BE VITAL in your career, Be seen for the talent you bring to your work. Explore opportunities within the Johnson & Johnson Family of Companies.
J2W: LI NA
J2W:BIO
J2W:NSJ
J2W:MZ
Primary Location:North America-United States-Pennsylvania-Spring House
Organization: Janssen Research & Development, LLC. (6084)
Job: R&D
Certain sites within the Johnson & Johnson family of companies participate in E-Verify as appropriate in accordance with Company guidelines and federal or state law. To learn more about the government sponsored program and to see a list of the sites that are currently enrolled, please click here.
Principal Scientist, Radiosynthesis-9489140122
Description
Janssen Research & Development, L.L.C., a Johnson & Johnson Company, is hiring a Principal Scientist, Radiosynthesis to be located in Spring House, PA.
Janssen Research & Development, L.L.C. develops treatments that improve the health and lifestyles of people worldwide. Research and development areas encompass novel targets in neurologic disorders, gastroenterology, oncology, infectious disease, diabetes, hematology, metabolic disorders, immunologic disorders, and reproductive medicine.
Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion, Janssen Research & Development, LLC is proud to be an equal opportunity employer.
Position is available in the Janssen Discovery Sciences, Isotope Synthesis Group located in Spring House Pa. The successful candidate will be responsible for the design, planning and synthesis of intermediates, stable and radioactive isotopic-labeled drug candidates and for the preparation of drug metabolites. Contingent on performance and experience the role may eventually include supervisory responsibilities for staff and postdocs.
Responsibilities include but are not limited to: Works closely with a small team of scientists involved in the production and analysis of carbon-14 and tritium labeled compounds; Assures projects move from inception to completion safely and in an acceptable timeframe and that specifications are attained which meet company goals; Ensures that appropriate standards are met in the analysis, release and stability investigation of isotopically labeled compounds; Communicates closely with internal and external partners and provides regular updates on project status; Liaises with study directors and project teams and provides up to date information on project status; Focuses on the synthesis and optimization of carbon-14 and tritium labeling methodologies as well as implementation of novel approaches to ensure timely delivery of highest quality products; Acts as a single point of contact for internal and external organizations requesting radiolabeled products; Responsible for planning own work and executing purification and release analysis of stable isotope labeled and carbon-14 and tritium labeled compounds. Assures agreed deadlines are met for delivery of analytically released compounds. Actively contributes to the planning of the operation and ensures appropriate use of resources internally and externally; Interacts with Bio-analytical and DMPK functions to ensure the provision of isotopically labeled (15N, 2H, 3H, 13C, 14C, etc.) compounds for various studies; Develops HPLC preparative purification methods for radiolytically decomposed radiolabeled materials; Analyzes and purifies radiolytically decomposed radiolabeled materials as required; Works closely with radiosynthesis scientists for optimization of carbon-14 and tritium labeling methodologies as well as implementation of novel synthesis approaches; Communicates project status and interacts on a regular basis with project leaders and functional (DMPK, Bio-analysis, and research) scientists; Ability to work in a team and constructively influence decision making; Writes reports and delivers presentations, which are clear, organized, focused, and intellectually sound; If training is required, the candidate must have a demonstrated aptitude for learning new techniques and operating varied pieces of scientific instruments and equipment; Maintains and follows all company SOPs and safety rules; Handles radioactivity in a safe manner and keeps equipment and laboratory environment free of radioactive contamination. Assures personnel, ecological and radiation safety standards are met; Appropriately documents and archives analytical raw data, datasheets and reports for analysis of isotopically and non-isotopically labeled compounds; supplies receipts and safety monitoring according to corporate policies; Tracks laboratory compound inventories and orders and replenishes own common lab supplies. Interacts with external suppliers, sales, and service individuals; Remains current in state-of-the-art techniques and technologies and ensures their implementation where appropriate; Takes responsibility for publishing activities and research in scientific and professional journals; May supervise staff in future where applicable; Assures state-of-the-art methodology, technology and equipment in the laboratory. Assures that all assisting study personnel have adequate training and understanding of all applicable SOPs; Complies with internal and external health and safety regulations and guidelines; Writes and follows Standard Operating Procedures; Completes all annual training requirements; Performs other duties as assigned.
Qualifications
PhD radiochemist with a minimum of 10 years of radiosynthesis experience working in a pharmaceutical radioisotope laboratory preparing and analyzing compounds labeled with carbon-14 and tritium is required
Extensive knowledge and expertise of with all aspects of radioisotope handling, methodologies and techniques is required
Extensive knowledge of the US NRC rules and regulations for radiation safety is required
Ability to manage multiple scientific projects; make sound scientific interpretations and judgments is required
Previous managerial experience is required
Proven track record of delivering high quality projects on time
Extensive technical experience in the performance of a range of niche radiolabeled reaction types and transformations that minimize the risk of contamination to personnel and environment is required
Extensive understanding of the pharmaceutical drug development business is required
Proven ability to lead and direct professional staff
Track record of innovation confirmed by senior-authored scientific publications in the radioisotope field
Thorough knowledge of analytical instruments, methodologies and techniques used for LC-MS and preparative HPLC chromatography and chiral methods development is required
Knowledge of NMR spectroscopy is required
Demonstrated ability to partner successfully in a fast paced, goal-oriented environment by building consensus and by impacting outcomes with limited supervision
Excellent verbal, partnering and communication skills with an innate ability to develop and articulate sound ideas and arguments to project leaders, scientific partners or clients
Proven track record of developing small molecule synthesis strategies and hands-on experience in synthetic chemistry completing synthesis projects is required
Can work independently with continuous attention to detail and safety
Possesses a strong analytical mindset coupled with strategic thinking abilities
Able to present clearly and effectively to scientists and all levels of management within and outside Discovery Science both locally and globally
Able to read, understand and verify accuracy of protocols and reports
Up to 5% travel, international and domestic may be required
BE VITAL in your career, Be seen for the talent you bring to your work. Explore opportunities within the Johnson & Johnson Family of Companies.
J2W: LI NA
J2W:BIO
J2W:NSJ
J2W:MZ
Primary Location:North America-United States-Pennsylvania-Spring House
Organization: Janssen Research & Development, LLC. (6084)
Job: R&D
Certain sites within the Johnson & Johnson family of companies participate in E-Verify as appropriate in accordance with Company guidelines and federal or state law. To learn more about the government sponsored program and to see a list of the sites that are currently enrolled, please click here.